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. 2024 Mar 20;13(6):1791. doi: 10.3390/jcm13061791

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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When the Hippo pathway is active (left), SAV1 and MST1/2 complex phosphorylates LATS1/2 and MOB1. Activated LATS1/2 subsequently phosphorylates the YAP/TAZ complex, resulting in cytoplasmic retention and no DNA transcription. Conversely, when the Hippo pathway is disrupted (right) during ovarian tissue fragmentation, dephosphorylated YAP1/TAZ translocates to the nucleus to bind with TEAD, leading to transcriptional activation of genes associated with cell growth and survival. Created with BioRender.com. Abbreviations: LATS1/2 (large tumor suppressor kinase 1/2); MOB1 (Mps one binder 1); MST1/2 (mammalian Ste20-like serine/threonine kinases 1/2); P (phosphorylated); SAV1 (protein salvador homolog 1; TEAD (TEA domain family members).