Table 8.
COX regression analysis for the hazard of reaching an EDSS of 6.0.
| Variable | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR. (95% IC) | p | HR. (95% IC) | p | |
| Gender (M vs. F) | 0.98 [0.64; 1.50] | 0.96 | - | - |
| Environment (Rural vs. Urban) | 1.18 [0.78; 1.80] | 0.42 | - | - |
| Age at onset (years) | 1.04 [1.02; 1.06] | <0.001 * | 1.04 [1.02; 1.06] | <0.001 |
| Onset Topography | 0.03 * | |||
| Infratentorial vs. Supratentorial | 1.42 [0.78; 2.59] | 0.24 | 1.24 [0.67; 2.27] | 0.48 |
| Mixt vs. Supratentorial | 1.47 [0.64; 3.34] | 0.35 | 0.93 [0.49; 2.15] | 0.87 |
| Optic vs. Supratentorial | 1.33 [0.69; 2.56] | 0.39 | 1.35 [0.69; 2.65] | 0.37 |
| Spinal vs. Supratentorial | 2.38 [1.38; 4.10] | 0.002 | 1.67 [0.95; 2.93] | 0.73 |
| EDSS_0 | 1.94 [1.73; 2.17] | <0.001 * | 1.94 [1.72; 2.19] | <0.001 |
| R_0 | 1.01 [0.91; 1.13] | 0.75 | - | - |
M: male; F: female; EDSS: expanded disability status scale (EDSS_0: at the patient’s first visit; R_0: relapses before treatment; HR = relative hazard; 95% CI: 95% confidence interval, * statistically significant result (p < 0.05).