Table 2.
The average motoric scores (CHOP INTEND, HFMSE, and RHS, respectively) by the time points in SMA 1, SMA 3p, and SMA 3a patients.
| Time of Evaluation | N of Patients | Motoric Score/X ± SD | Change from Baseline | p Value | ||||
|---|---|---|---|---|---|---|---|---|
| SMA 1 | ||||||||
| Baseline | 6 | 33.7 ± 23.7 | N/A | 0.067 | ||||
| 6 months after switch | 6 | 34.3 ± 23.6 | 0.6 | |||||
| 12 months after switch | 6 | 34.7 ± 23.3 | 1.0 | |||||
| SMA 3p | ||||||||
| Baseline | 4 | 54.8 ± 10.2 | N/A | 0.897 | ||||
| 6 months after switch | 4 | 55.0 ± 10.2 | 0.2 | |||||
| 12 months after switch | 4 | 55.5 ± 11.3 | 0.7 | |||||
| SMA 3a | ||||||||
| Baseline | 7 * | 6 | 39.1 ± 12.7 * | 39.5±13.9 | N/A * | N/A | N/A * | 0.463 |
| 6 months after switch | 40.0 ± 13.1 * | 40.5±14.3 | 0.9 * | 1.0 | 0.141 * | |||
| 12 months after switch | N/A * | 40.3 ± 15.6 | N/A * | 0.8 | N/A * | |||
* For all comparisons, the Friedman test was used, except for those marked with *, where the Wilcoxon test was used.