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Inclusion criteria
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| Age between 18 and 65 |
| Veterans with MOSs during service defined to be high-risk that are associated with exposures to blast during training and/or combat. These can include Cannon Crewmembers, Explosive Ordinance Disposal Specialists, Fire Infantrymen, Combat Engineers, and Special Forces etc. |
| Exposure to repeated blasts as part of military duties |
| Score of 2 of greater on at least one Neurobehavioral Symptom Questionnaire (NSI) symptom |
| Ability to provide informed consent |
| Willingness to provide blood |
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Exclusion criteria
|
| Inability to adequately respond to questions regarding the informed consent procedure |
| Currently involved in the criminal justice system as a prisoner or ward of the state |
| Non-English speaking |
| Current occupation involving shift work |
| Female Veteran who is pregnant |
| Lifetime history of bipolar disorder or psychosis |
| History of moderate or severe TBI |
| Changes in regularly used medications (e.g., daily) in the last month for medications known to impact sleep (e.g., benzodiazepines, etc.) |
| Current chronic steroid use |
| History of neurological or neurodegenerative disease such as multiple sclerosis |
| History of brain tumor |
| History of seizure disorder unrelated to TBI |
| History of HIV/AIDS |
| Current systemic illness such as uncontrolled diabetes mellitus, hypo- or hyperthyroidism, or systemic cancer |
| Acute disease at the time of enrollment (defer sampling until subject recovers). Acute disease is defined as the presence of a moderate or severe illness with or without fever |
