Table 3.

microCT data of the vertebrae L5 in 12-, 24-, and 48-wk-old female and male osteoclast-specific Pls3 KO mice in comparison to their Pls3-floxed control littermates.

microCT of spine L5		12 wk	24 wk	48 wk
		Pls3  fl/fl;LysMCre vs Pls3fl/fl	Pls3  fl/fl;LysMCre vs Pls3fl/fl	Pls3  fl/fl;LysMCre vs Pls3fl/fl
BV/TV (%)	Female	ns	ns	ns
	Male	ns	ns	ns
BMD (mgHA/cm3)	Female	ns	ns	ns
	Male	ns	ns	ns
Tb.N (1/mm)	Female	ns	ns	ns
	Male	* * increase	ns	ns
Tb.Sp (mm)	Female	ns	ns	ns
	Male	* decrease	ns	ns
Tb.Th (mm)	Female	ns	ns	ns
	Male	ns	ns	ns
Conn.D (1/mm3)	Female	ns	ns	ns
	Male	ns	ns	ns
Vertebral foramen A/P (mm)	Female	ns	ns	ns
	Male	ns	ns	ns
Vertebral foramen M/L (mm)	Female	ns	ns	ns
	Male	ns	ns	ns
Cross-sectional area vertebral foramen (mm2)	Female	ns	ns	ns
	Male	ns	ns	ns
Vertebral body height (mm)	Female	ns	ns	ns
	Male	ns	ns	ns

Shown are bone volume fraction (BV/TV, %), BMD (mgHA/cm³), trabecular number (Tb.N, 1/mm), trabecular separation (Tb.Sp, mm), trabecular thickness (Tb.Th, mm), and connectivity density (Conn.D, 1/mm³), vertebral foramen A/P (mm), vertebral foramen M/L (mm), cross-sectional area of the vertebral foramen (mm²), and vertebral body height (mm). N = 8 of 12-wk-old female Pls3^fl/fl;LysMCre^tg/0 mice; N = 12 of 12-wk-old female Pls3^fl/fl mice; N = 12 of 12-wk-old male Pls3^fl;LysMCre^tg/0 mice; N = 11 of 12-wk-old male Pls3^fl mice; N = 11 of 24-wk-old female Pls3^fl/fl;LysMCre^tg/0 mice; N = 13 of 24-wk-old female Pls3^fl/fl mice; N = 13 of 24-wk-old male Pls3^fl;LysMCre^tg/0 mice; N = 11 of 24-wk-old male Pls3^fl mice; N = 3 of 48-wk-old female Pls3^fl/fl;LysMCre^tg/0 mice; N = 5 of 48-wk-old female Pls3^fl/fl mice; N = 5 of 48-wk-old male Pls3^fl;LysMCre^tg/0 mice; N = 4 of 48-wk-old male Pls3^fl mice. All results are shown as mean ± SEM. ^*P < .05, ^**P < .01, ^***P < .001, ns = not significant. An increase or decrease in comparison to the control group is indicated. Statistical test: Mann–Whitney U test.