Figure 2.

Graphical representation of the main characteristics of articles included in this systematic review. (A) Number of articles published per year (2013–2023) included for analysis in this systematic review. (B) Taxonomic categorization into subclass and order is performed for marine sponges serving as sources of compounds and extracts or as inspiration for synthesis. The number of articles is indicated in parentheses. (C) Graphical representation of the method for obtaining compounds included in this systematic review, quantifying the number of articles and compounds associated with each methodology. (D) Number of publications in which each cell line is used and its classification.