Table 3.
Association between ADIPOQ polymorphisms and LOAD risk in the whole study population.
| ADIPOQ SNPs | LOAD (n = 385) |
Controls (n = 533) |
Logistic Regression Analysis (Log-Additive Model) |
|||
|---|---|---|---|---|---|---|
| Genotypes a | MAF | Genotypes a | MAF | p-Value | OR (95% CI) | |
| rs822387 T>C | 336/46/3 | 0.0675 | 463/65/5 | 0.0704 | 0.64 | 0.91 (0.62–1.34) |
| rs860291 C>T | 301/80/4 | 0.1143 | 425/105/3 | 0.1041 | 0.54 | 1.11 (0.80–1.53) |
| rs17300539 G>A | 335/49/1 | 0.0662 | 457/70/6 | 0.0769 | 0.32 | 0.82 (0.56–1.21) |
| rs266729 C>G | 206/147/32 | 0.2740 | 279/211/43 | 0.2786 | 0.66 | 0.95 (0.76–1.18) |
| rs182052 G>A | 151/175/59 | 0.3805 | 212/252/69 | 0.3659 | 0.72 | 1.04 (0.85–1.27) |
| rs822393 C>T | 213/139/33 | 0.2662 | 296/205/32 | 0.2523 | 0.36 | 1.11 (0.89–1.39) |
| rs822395 A>C | 170/167/48 | 0.3416 | 240/229/64 | 0.3349 | 0.86 | 0.98 (0.80–1.21) |
| rs822396 A>G | 256/115/14 | 0.1857 | 358/159/16 | 0.1792 | 0.80 | 0.97 (0.75–1.25) |
| rs7627128 C>A | 269/106/10 | 0.1636 | 363/153/17 | 0.1754 | 0.59 | 0.93 (0.71–1.21) |
| rs2036373 T>G | 343/42/0 | 0.0545 | 475/57/1 | 0.0553 | 0.62 | 1.12 (0.72–1.75) |
| rs17366568 G>A | 302/79/4 | 0.1130 | 401/127/5 | 0.1285 | 0.47 | 0.89 (0.65–1.22) |
| rs17846866 T>G | 329/56/0 | 0.0727 | 464/67/2 | 0.0666 | 0.48 | 1.15 (0.77–1.72) |
| rs2241766 T>G | 304/77/4 | 0.1104 | 427/100/6 | 0.1051 | 0.66 | 1.08 (0.78–1.48) |
| rs1501299 G>T | 184/167/34 | 0.3052 | 270/215/48 | 0.2917 | 0.24 | 1.14 (0.92–1.41) |
| rs2241767 A>G | 306/77/2 | 0.1052 | 430/97/6 | 0.1022 | 0.79 | 1.05 (0.75–1.46) |
| rs3821799 C>T | 112/191/82 | 0.4610 | 168/251/114 | 0.4493 | 0.28 | 1.12 (0.92–1.36) |
| rs3774261 G>A | 134/186/65 | 0.4104 | 202/242/89 | 0.3940 | 0.21 | 1.14 (0.93–1.39) |
| rs1063539 G>C | 302/80/3 | 0.1117 | 423/104/6 | 0.1088 | 0.84 | 1.03 (0.75–1.43) |
a Genotype numbers are presented as follows: major allele homozygotes/heterozygotes/minor allele homozygotes. Logistic regression analysis was adjusted for age, sex, APOE ε4 carrier status, hypertension, type 2 diabetes mellitus, and body mass index. P, OR, and 95% CI values are shown for the log-additive model. Values obtained by crude analysis and under other genetic models are presented in Supplementary Table S5. ADIPOQ: adiponectin gene; CI: confidence interval; LOAD: late-onset Alzheimer’s disease; MAF: minor allele frequency; OR: odds ratio; SNP: single nucleotide polymorphism.