Table 2.
Distribution of threshold values of inflammatory markers according to cervico-vaginal cytology findings.
| Inflammatory Markers Predictive Value, pg/mL |
Area under ROC Curve, % |
Sensitivity/ Specificity, % |
NILM/ CC, n (%) |
p Value | CC Group OR [95% PI] |
|---|---|---|---|---|---|
| IFN-β > 79.0 | 58.2 | 86.2 35.2 |
57 (64.8) 81 (86.2) |
0.001 | 3.389 [1.632–7.038] |
| IFN-γ > 1972.7 | 65.9 | 46.8 85.2 |
13 (14.8) 44 (46.8) |
<0.001 | 5.077 [2.484–10.375] |
| IL-1β > 145.3 | 65.4 | 86.2 42.0 |
51 (58.0) 81 (86.2) |
<0.001 | 4.52 [2.195–9.31] |
| IL-10 ≤ 1472.5 | 66.8 | 79.8 51.1 |
43 (48.9) 75 (79.8) |
<0.001 | 4.131 [2.147–7.947] |
| LCN2 > 23,721.5 | 69.9 | 59.6 83.0 |
15 (17.0) 56 (59.6) |
<0.001 | 7.172 [3.591–14.323] |
| TREM-1 > 355.6 | 75.0 | 55.3 88.6 |
10 (11.4) 52 (55.3) |
<0.001 | 9.657 [4.455–20.936] |
| TNF-α > 17.6 | 90.0 | 96.8 81.6 |
16 (18.4) 91 (96.8) |
<0.001 | 134.604 [37.742–480.06] |
| IL-6 > 17.4 | 84.6 | 80.6 75.9 |
21 (24.1) 75 (80.6) |
<0.001 | 13.095 [6.431–26.667] |
OR—odds ratio; CI—confidence interval; CC—cervical cancer; NILM—negative for intraepithelial lesions or malignancy.