Table 2.
Antimicrobial activity of representative compounds in the RAL library 1.
| Compound | MIC90 (µM) | |||||
|---|---|---|---|---|---|---|
| M. marinum | S. aureus | E. coli | P. aeruginosa | C. albicans | A. fumigatus | |
| 1 | >200 | >100 | >100 | >100 | >100 | >100 |
| 4 | >200 | 12.5 | >100 | >100 | >100 | >100 |
| 11 | 100 | >100 | >100 | >100 | >100 | >100 |
| 12 | 80 | >100 | >100 | >100 | >100 | >100 |
| 18 | >200 | >100 | >100 | >100 | >100 | >100 |
| 19 | 90 | >100 | >100 | >100 | >100 | >100 |
| 20 | 80 | >100 | >100 | >100 | >100 | >100 |
| 22 | 80 | >100 | >100 | >100 | >100 | >100 |
| Isoniazid | 40 | nt | nt | nt | nt | nt |
| Rifampicin | 10 | nt | nt | nt | nt | nt |
| Ciprofloxacin | nt | 3.13 | 0.10 | 1.56 | nt | nt |
| Amphotericin B | nt | nt | nt | nt | 0.84 | 0.07 |
1 Results are the average of three independent experiments, each performed in duplicate. Standard deviations were less than ±10%. nt = not tested.