Table 3.
Baseline characteristics of the study participants stratified by kidney dysfunction (KD) and according to the SUA/sCr ratio threshold, which is predictive for cardiovascular mortality.
| Variables | KD [−] > 60 mL/min/1.73 m2 | KD [+] ≤ 60 mL/min/1.73 m2 | ||
|---|---|---|---|---|
| SUA/sCr Ratio | SUA/sCr Ratio | |||
| ≤5.35 | >5.35 | ≤5.35 | >5.35 | |
| No. of participants | 702 | 995 | 336 | 197 |
| Age (years) | 60.9 (12.4) | 63.9 (12.6) * | 72.4 (10.0) | 72.6 (9.8) |
| Gender (M/F%) | 59.9/40.1 | 55.4/44.6 | 36.6/63.4 | 23.9/76.1 * |
| Cigarette Smoking (%) | 23.1 | 17.6 * | 13.7 | 12.7 |
| BMI (kg/m2) | 27.8 (4.4) | 29.1 (4.6) * | 27.9 (4.7) | 29.3 (4.5) * |
| Normal-weight (%) | 25.0 | 17.5 | 29.0 | 14.4 |
| Overweight (%) | 46.9 | 46.0 | 42.6 | 45.6 |
| Obesity (%) | 28.1 | 36.5 * | 28.4 | 40.0 * |
| Systolic BP (mmHg) | 149.7 (26.1) | 151.4 (26.2) * | 154.6 (25.5) | 156.6 (25.0) |
| Diastolic BP (mmHg) | 84.9 (12.1) | 85.4 (12.2) | 85.4 (12.9) | 86.1 (14.4) |
| Hypertension (%) | 69.5 | 76.2 * | 84.2 | 86.3 |
| Creatinine (mg/dL) a | 0.91 (1.2) | 0.84 (1.2) * | 1.26 (1.3) | 1.11 (1.1) * |
| eGFR (mL/min/1.73 m2) a | 79.4 (1.2) | 85.1 (1.3) * | 44.7 (1.3) | 51.3 (1.1) * |
| Serum Uric Acid (mg/dL) a | 3.9 (1.3) | 5.8 (1.2) * | 4.8 (1.3) | 7.1 (1.2) * |
| Glucose (mg/dL) a,b | 135.8 (1.4) | 131.0 (1.3) | 141.2 (1.4) | 138.6 (1.3) |
| Total cholesterol (mg/dL) a,c | 208.9 (1.2) | 208.4 (1.2) | 200.0 (1.24) | 210.2 (1.2) * |
| Triglycerides (mg/dL) a | 125.9 (1.7) | 134.9 (1.7) * | 141.2 (1.7) | 162.2 (1.7) * |
| HDL-cholesterol (mg/dL) a,d | 46.8 (1.3) | 47.9 (1.3) | 46.8 (1.4) | 46.8 (1.3) |
| Triglycerides(mg/dL)/HDL-cholesterol (mg/dL) d | 3.7 (2.8) | 3.6 (3.3) | 3.9 (3.1) | 4.4 (3.3) |
| Statin use (%) | 4.0 | 7.6 * | 8.6 | 8.2 |
Data are expressed as means (SD): BMI: body mass index; BP: Blood Pressure; eGFR: estimated glomerular filtration rate. Overweight was defined as a BMI between 25 and 29.9 kg/m2 and obesity as BMI ≥ 30 kg/m2. Hypertension was defined as office systolic BP ≥ 140 and/or diastolic BP ≥ 90 mmHg or current antihypertensive drug treatment. a Data are expressed as geometric mean (SD); b sample reduced by 15%; c sample reduced by 5%; d sample reduced by 20%; * >5.35 vs. ≤5.35: p < 0.05.