Table 4.

Cox-regression analysis of the risk of cardiovascular mortality according to kidney dysfunction (KD).

	KD[−]	KD[+]
	SUA/sCr Ratio >5.35 vs. ≤5.35	SUA/sCr Ratio >5.35 vs. ≤5.35
	HR (95% CI *)	HR (95% CI *)
Unadjusted	1.62 (1.23–2.20) §	0.96 (0.66–1.35)
Multivariable Model 1 a	1.32 (1.01–1.74) §	1.01 (0.72–1.42)
Multivariable Model 2 b	1.35 (1.01–1.81) §	0.98 (0.69–1.40)
Multivariable Model 3 c	1.61 (1.15–2.26) §	0.98 (0.65–1.48)
Multivariable Model 4 d	1.58 (1.11–2.23) §	0.97 (0.64–1.49)

Hypertension was defined as office systolic BP ≥ 140 and/or diastolic BP ≥ 90 mmHg or current antihypertensive drug treatment; HR: Hazard Ratio; KD[−]: >60 mL/min/1.73 m²; KD[+]: ≤60 mL/min/1.73 m²; SUA/sCr ratio: serum uric acid/serum creatinine ratio; * Bootstrap confidence intervals (1000 iterations); ^§ p < 0.05. ^a Model 1 adjusted for baseline age, gender, body weight, hypertension, and cigarette smoking. ^b Model 2 adjusted for Model 1 plus baseline (log)total cholesterol, (log)triglycerides, and statin use (sample reduced by 5%). ^c Model 3 adjusted for Model 2 plus baseline (log) blood glucose (sample reduced by 15%). ^d Model 4 adjusted for Model 3 plus baseline (log)HDL-cholesterol (sample reduced by 20%).