Table 2.
Cox hazards model analysis of variables at diagnosis for all-cause mortality during follow-up in patients with AAV.
| Variables | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| Age | 1.089 | 1.048, 1.133 | <0.001 | 1.061 | 1.017, 1.107 | 0.006 |
| Male sex * | 2.913 | 1.441, 5.891 | 0.003 | |||
| BMI * | 1.114 | 1.015, 1.223 | 0.024 | |||
| Smoking history | 1.902 | 0.453, 7.980 | 0.380 | |||
| MPO-ANCA (or P-ANCA) positivity | 2.0117 | 0.827, 4.918 | 0.123 | |||
| PR3-ANCA (or C-ANCA) positivity | 0.170 | 0.023, 1.248 | 0.082 | |||
| BVAS | 1.086 | 1.037, 1.138 | <0.001 | 1.051 | 0.993, 1.112 | 0.088 |
| FFS | 2.019 | 1.444, 2.823 | <0.001 | 1.286 | 0.844, 1.959 | 0.242 |
| ESR | 1.012 | 1.003, 1.022 | 0.010 | 1.000 | 0.988, 1.012 | 0.962 |
| CRP | 1.009 | 1.004, 1.014 | <0.001 | 1.004 | 0.998, 1.011 | 0.214 |
| Type 2 diabetes mellitus | 1.090 | 0.514, 2.311 | 0.822 | |||
| Arterial hypertension | 1.374 | 0.686, 2.752 | 0.370 | |||
| Hyperlipidaemia | 1.761 | 0.833, 3.723 | 0.139 | |||
| ANI ≥ −0.59 | 2.550 | 1.228, 5.296 | 0.012 | 2.479 | 1.149, 5.349 | 0.021 |
*: Because male sex and BMI are the parameters of the equation for ANI, they were not included in the multivariable Cox analysis. AAV: ANCA-associated vasculitis; ANCA: antineutrophil cytoplasmic antibody; HR: hazard ratio; CI: confidence interval; BMI: body mass index; MPO: myeloperoxidase; P: perinuclear; PR3: proteinase 3; C: cytoplasmic; BVAS: Birmingham Vasculitis Activity Score; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; ANI: the alcoholic liver disease/nonalcoholic fatty liver disease index.