Table 2.
Clinical oxygen characteristics of SARS-CoV-2-infected individuals receiving high-flow oxygen, low-flow oxygen, and no oxygen.
| High Flow | Low Flow | No Oxygen | p-Value a | p-Value b | p-Value c | |
|---|---|---|---|---|---|---|
| N (%) | 11 (27.50) | 23 (57.5) | 6 (15) | - | - | - |
| Age, yr, median (IQR) d | 56 (44–65) | 58 (51–64) | 52 (35–58) | 0.6174 | 0.362 | 0.0866 |
| Female sex (%) e | 4 (36.40) | 8 (34.8) | 2 (33.33) | 0.9281 | 0.9006 | 0.9470 |
| Baseline SaO2 (%), median (IQR) d | 94 (91–96) | 94(93–96) | 96 (95.5–97) | 0.4683 | 0.0376 | 0.0991 |
| Baseline FIO2, median (IQR) d | 0.21 (0.21–0.21) | 0.21 (0.21–0.21) | 0.21 (0.21–0.21) | 0.0980 | 0.5147 | >0.9999 |
| Baseline ABG PaO2 (mmHg), median (IQR) d | 52 (49–69) | 69.5 (62.5–76.25) | 76 (71–86) | 0.0807 | 0.0353 | 0.1247 |
| Baseline ABG FIO2, median (IQR) d | 0.21 (0.21–0.24) | 0.21 (0.21–0.21) | 0.21 (0.21–0.21) | 0.0891 | 0.5089 | >0.9999 |
| Baseline ABG PaO2/FIO2, median (IQR) d | 246 (158–328.6) | 317 (283.8–363.1) | 361.9 (338–409) | 0.0365 | 0.038 | 0.1091 |
| 48 h SaO2 (%), median (IQR) d | 95 (92–96) | 96 (95–97) | 96 (93.5–97.75) | 0.0693 | 0.3848 | 0.6678 |
| 48 h FIO2, median (IQR) d | 0.4 (0.28–0.5) | 0.28 (0.275–0.32) | 0.21 (0.21–0.2275) | 0.0171 | 0.0006 | 0.0058 |
| 48 h ABG PaO2 (mmHg), median (IQR) d | 75 (69–90) | 79 (75–104) | 74 (64–107) | 0.3681 | >0.9999 | 0.4982 |
| 48 h ABG FIO2, median (IQR) d | 0.4 (0.28–0.8) | 0.28 (0.225–0.32) | 0.21 (0.21–0.21) | 0.0939 | 0.0165 | 0.0571 |
| 48 h ABG PaO2/FIO2, median (IQR) d | 194 (118–314) | 304 (237–382.5) | 352 (304–510) | 0.0257 | 0.0385 | 0.2839 |
| MDW (U), median (IQR) d | 22.24 (20.33–26.48) | 23.76 (21–28.17) | 24.57 (21.18–25.55) | 0.3171 | 0.5035 | 0.7455 |
| aPTT (s), median (IQR) d | 12.9 (11.7–14.15) | 12.5 (11.8–13.2) | 12.9 (12.28–14.08) | 0.5675 | 0.7714 | 0.2284 |
| aPTT (%), median (IQR) d | 78.5 (69–89.25) | 82 (74–88) | 77.5 (70.5–82.25) | 0.6522 | 0.7717 | 0.1876 |
| PT/INR, median (IQR) d | 1.21 (1.07–1.305) | 1.15 (1.088–1.223) | 1.29 (1.16–1.31) | 0.5452 | 0.6273 | 0.1059 |
| pH, median (IQR) d | 7.44 (7.435–7.47) | 7.45 (7.4–7.475) | 7.43 (7.365–7.465) | 0.6684 | 0.3776 | 0.4402 |
| Partial Pressure CO2 (mmHg), median (IQR) d | 43 (36.5–83) | 38 (35.5–47.5) | 35.5 (34.25–47.25) | 0.3203 | 0.2567 | 0.4605 |
| Partial Pressure O2 (mmHg), median (IQR) d | 73.5 (41.5–83.5) | 69 (36–88) | 90 (37.25–132.3) | 0.7161 | 0.4356 | 0.4101 |
| HCO3 (mmol/L), median (IQR)d | 26.3 (23.5–29.38) | 26 (24.05–27.75) | 24.9 (22.55–27.7) | 0.7313 | 0.4336 | 0.5992 |
| Base excess (mmol/L), median (IQR) d | 3.2 (0.05–4.7) | 2.1 (0.05–3.35) | 0.6 (−1.375–2.275) | 0.4220 | 0.1878 | 0.2553 |
| O2 Saturation (%), median (IQR) d | 97.6 (96.18–99.7) | 95.6 (78.2–98.3) | 97.5 (35.4–98.2) | 0.0302 | 0.5035 | >0.9999 |
a High flow vs. low flow, b high flow vs. no oxygen, c low flow vs. no oxygen, d Mann–Whitney t test, e Chi-square test. Interquartil range (IQR). Arterial blood gas (ABG), monocyte distribution width (MDW), activated partial thromboplastin time (aPTT), prothrombin time/international normalized Ratio (PT/INR).