Table 3.

Impact of radiotherapy on prepectoral breast reconstruction.

Study	Year	Findings
Apte A et al. [64]	2019	The study looked at implant-based reconstruction with ADM with and without radiotherapy; this showed no significant difference in the revision surgeries in the two groups. However, the rate of capsular contracture was higher in the PMRT group
Zugasti et al. [57]	2021	This study showed significantly higher rates of surgical complications, reoperation rates, and reconstruction failure among patients who underwent PMRT after immediate IBBR. They reported a decreased level of satisfaction and unfavorable aesthetic results attributable to PMRT
Awadeen et al. [47]	2023	This study illustrates a significantly higher rate of wound infection, capsular contracture, implant loss, and poor aesthetic results among patients with PPBR and PMRT. However, there was no significant difference between PMRT and non-PMRT for wound dehiscence, seroma, hematoma, nipple necrosis, and breast rippling
Polloto et al. [61]	2023	This study demonstrates that ADM-assisted PPBR patients who underwent PMRT presented a low complication rate and minimal need for revisional surgery in the long-term follow-up, suggesting that this technique is also feasible and safe in the PMRT context

PPBR—prepectoral breast reconstruction, ADM—acellular dermal matrix, PMRT—post-mastectomy radiation therapy.