Table 3.

Cases reported to have eruptive keratoacanthoma of Grzybowski.

Study	Diagnosis	Syndrome	Age/Gender	Lesion Description	Lesion Location	Treatment Plan
[19]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	80/F	Numerous follicular nodules and crateform tumors	KAs: the legs, arms, and trunk and limbs	Surgical removal of the largest skin lesions, oral acitretin (0.5 mg/kg/day)
[20]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	64/M	Umbilicated papules and small follicular papules	KAs: face, upper limbs, and trunk; the oral mucosa	Retinoids (no specific treatment reported)
[21]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	70/F	Numerous follicular papules and several erythematous nodules with keratotic centers	KAs: upper limbs, lower limbs, and trunk	Surgical removal of the largest skin lesions Initial treatment that failed: oral acitretin (0.5 mg/kg/day) Treatment that succeeded: subcutaneous methotrexate (MTX) 15 mg/week
[22]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	63/M	Hyperkeratotic erythematous nodules	KAs: ear lobe, cheeks, nose, arm, shoulder	Complete excision, sorafenib withdrawal
[23]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	51/M	Scaly and ulcerated papules and nodules	KAs: upper and lower extremities	Topical imiquimod 5% cream once daily on five continuous days of the week plus lapacho tea dressings
[24]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	83/F	Multiple skin-colored to erythematous to brownish papules, with a keratotic center	KAs: face	Acitretin up to 25 mg daily
[25]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	46/F	Keratotic, dome-shaped, follicular-based papules and scattered crateriform keratotic papules	KAs: trunk and extremities	Photodynamic therapy, oral acitretin up to 25 mg daily
[26]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	66/M	Large keratotic papules	KAs: face, neck, and chest	Acitretin up to 25 mg/d and doxepin
[27]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	47/F	Skin-colored follicular papules, papules with central umbilication, and larger lesions with a central crater	KAs: face, neck, and trunk	Initial failed treatment approach: acitretin (firstly) and methotrexate (secondly) Cyclophosphamide pulse therapy was then started at a dose of 1 g monthly
[27]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	59/F	Skin-colored follicular papules, papules with central umbilication, and larger lesions with a central crater	KAs: face, neck, and trunk	Initial failed treatment approach: acitretin (firstly) and methotrexate (secondly) Cyclophosphamide pulse therapy was then started at a dose of 1 g monthly
[27]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	68/M	Skin-colored follicular papules, papules with central umbilication, and larger lesions with a central crater	KAs: face, neck, and trunk	Initial failed treatment approach: acitretin Lost to follow up
[28]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	57/F	Multiple papules	KAs: upper trunk, arms and hands	Excision of large lesions Acitretin up to 25 mg daily; cyclophosphamide up to 200 mg daily
[29]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	71/F	Scattered, hyperkeratotic papules with central ulcers	KAs: right wrist and anterior aspects of the shins	Excision (Mohs’ micrographic surgery)
[7]	Clinical presentation	Eruptive keratoacanthoma of Grzybowski	58/M	Multiple pruritic papules and nodular and papular erythematous lesions	KAs: head, trunk, neck, and shoulder	Initial failed treatment approach: acitretin, 1 mg kg daily; methotrexate, 15 mg weekly; subcutaneous interferon a-2a and psoralen plus ultraviolet (UV) A therapy No successful treatment plan reported

KA: keratoacanthoma.