Figure 5.

Differential gene expression of genes involved in IL-17 pathway (upper panel (A,B)), Retinol metabolism (middle panel (C,D)), and “chemical carcinogenesis” (lower panel (E,F)) are shown. Gene expression data for MSI tumors are shown in left panels, and MSS tumors are shown in the right panels. CRC tissue (in blue) is compared to corresponding normal tissue (in red). The x-axis represents the gene probes, and the y-axis shows their Log₂ transformed expression value. The average magnitude of overexpression of the IL-17 pathway was significantly higher (ANOVA interaction p = 0.0009) for MSI tumors. The down-regulation of “retinol metabolism pathway” (ANOVA interaction p = 0.0001) and genes involved in “chemical carcinogenesis” (ANOVA interaction p = 6.15 × 10⁻⁵) was more marked in MSI tumors.