Table 2.

Technical, data-related and functional criteria) (18)

Technical criteria	Data criteria	Functional criteria
T1—Date of the last version	D1—Format of the schema	F1—Allowance of multi-label annotations	F8—Allowance for saving documents partially
T2—Availability of the source code	D2—Input format for documents	F2—Allowance of document-level annotations	F9—Ability to highlight parts of the text
T3—Online availability for use	D3—Output format for annotations	F3—Support for annotation of relationships	F10—Support for users and teams
T4—Easiness of installation		F4—Support for ontologies and terminologies	F11—Support for inter-annotator agreement
T5—Quality of the documentation		F5—Support for pre-annotations	F12—Data privacy
T6—Type of license		F6—Integration with PubMed	F13—Support for various languages
T7—Free of charge		F7—Suitability for full texts

Publication criteria have been excluded as they do not apply for the comparison conducted in this paper.