Table 3. TWAS and colocalization analysis identified genes involved in multiple phenotypes.
| Gene name | Position | Phenotype | TWAS Z-score | TWAS p val | Perm p val | Model p val | PP.H3 | PP.H4 |
|---|---|---|---|---|---|---|---|---|
| S100A9 | 1q21.3 | Neutrophil | 7.225 | 5.0 × 10−13 | 0 | 1.7 × 10−17 | 0.035 | 0.962 |
| Periodontitis | −3.564 | 3.7 × 10−4 | 1.3 × 10−3 | 1.7 × 10−17 | 0.008 | 0.259 | ||
| S100A12 | 1q21.3 | Neutrophil | 7.310 | 2.7 × 10−13 | 1.7 × 10−4 | 4.1 × 10−43 | 0.027 | 0.970 |
| Periodontitis | −3.513 | 4.4 × 10−4 | 8.1 × 10−4 | 4.1 × 10−43 | 0.008 | 0.244 | ||
| MCM6 | 2q21.3 | Neutrophil | −5.549 | 2.9 × 10−8 | 0 | 3.5 × 10−13 | 0 | 0.999 |
| Plasmacytoid DC | 7.172 | 7.4 × 10−13 | 2.7 × 10−3 | 3.5 × 10−13 | 1.000 | 0 | ||
| PI4KAP2 | 22q11.21 | Neutrophil | 5.345 | 9.0 × 10−8 | 3.3 × 10−3 | 3.7 × 10−39 | 0.003 | 0.016 |
| Plasmacytoid DC | 5.322 | 1.0 × 10−7 | 3.2 × 10−3 | 3.7 × 10−39 | 0.009 | 0.045 |
DC, dendritic cell; Perm, permutation test; PP, posterior probability; TWAS, transcriptome-wide association study.