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. Author manuscript; available in PMC: 2024 Mar 27.
Published in final edited form as: World J Biol Psychiatry. 2022 Oct 6;24(5):333–386. doi: 10.1080/15622975.2022.2112074

Table 1.

Summary of recommendations

Strength of supporting evidence / evidence statement phrasing
Grade B / could
Grade C1 / may
Grade C3 / may
Domain Recommendation statement Level of evidence Recommendation Grade
5.1 Physical activity and exercise interventions Physical activity and exercise interventions could be used to reduce depressive symptoms in people with Major Depressive Disorder Limited; Grade B 2
5.2 Smoking cessation interventions Smoking cessation interventions that involve counselling and/or pharmacotherapy (e.g., nicotine replacement) may be used to reduce depressive symptoms in current smokers with Major Depressive Disorder Low; Grade C3 3
5.3 Work-directed interventions A combination of work focused counselling and work-directed interventions could be used to reduce depressive symptoms in people with Major Depressive Disorder Limited; Grade B 2
5.4 Mindfulness-based and stress management interventions Mindfulness-based therapies (e.g., Mindfulness Based Cognitive Therapy [MBCT] and Mindfulness Based Stress Reduction [MBSR]) could be used to reduce depressive symptoms in people with Major Depressive Disorder Limited; Grade B 2
Stress management and relaxation techniques (e.g., breathing techniques, progressive muscle relaxation, coping skills training) could be used to reduce depressive symptoms in people with Major Depressive Disorder Limited; Grade B 2
5.5 Dietary interventions Dietary counselling to improve nutritional habits that is in line with healthy dietary guidelines and/or nutrient-dense dietary patterns may be used to reduce depressive symptoms in people with Major Depressive Disorder Low; Grade C1 3
5.6 Sleep-related interventions Cognitive behavioral therapy for insomnia (CBT-I) could be used to reduce depressive symptoms in people with Major Depressive Disorder Limited; Grade B 2
5.7 Loneliness and Social support- related interventions Improving social support and reducing loneliness may be used to reduce depressive symptoms in people with Major Depressive Disorder Low; Grade C3 3
5.8 Green space interventions Support regarding individualized interaction with green spaces or participation in a green space-focused program may be used to reduce depressive symptoms in people with Major Depressive Disorder Low; Grade C1 3