Statement: Cognitive behavioral therapy for insomnia (CBT-I) could be used to reduce depressive symptoms in people with Major Depressive Disorder (Grade B evidence).

Recommendation Grade: 2

Strength of evidence: Limited; Grade B Acceptability: Good

Clinical recommendation was based on: 1x Meta-analysis (k=8 studies, N= 491 participants)(Selvanathan et al. 2021) Reported effect size: Medium effect size (standardized mean difference=0.5) Risk of bias assessment: Low ROB meta-analyses of high ROB individual trials.