Table 1. New 2023 FIGO staging system of carcinoma of the endometrium (adapted from Berek et al) 1 .
FIGO Stage | Carcinoma endometrium descriptors |
---|---|
Stage I | Lesion confined to the body of uterus and the ovary |
IA | Disease limited only to the endometrium/a nonaggressive histological type (low-grade endometroid carcinoma), with invasion of <50% myometrium with no or focal LVSI/a good prognosis disease IA1: Nonaggressive histological type limited to an endometrial polyp/confined to endometrium only IA2: Nonaggressive histological types involving <50% myometrium with no or focal LVSI IA3: Low-grade endometrioid carcinomas limited to uterus and ovary (good prognosis disease) |
IB | Nonaggressive histological types with invasion of ≥ 50% of the myometrium, and with either no or only focal LVSI |
IC | Aggressive histological types limited to a polyp or lesion confined to the endometrium |
Stage II | Nonaggressive histological types with invasion of cervical stroma without extrauterine extension/with substantial LVSI OR an aggressive histological type with myometrial invasion |
IIA | Nonaggressive histological types with invasion of the cervical stroma |
IIB | Nonaggressive histological types with substantial LVSI |
IIC | Aggressive histological types with any degree of myometrial involvement |
Stage III | Tumor of any histological subtype with local and/or regional spread |
IIIA | Invasion of uterine serosa or adnexa or both; either by direct extension or metastasis IIIA1: Spread to ovary/fallopian tube (except when meeting criteria of stage IA3) IIIA2: Involvement of uterine subserosa/spread through uterine serosa |
IIIB | Metastasis or direct spread to vagina and/or to parametria or the pelvic peritoneum IIIB1: Metastasis or direct spread to vagina and/or parametria IIIB2: Metastasis to pelvic peritoneum |
IIIC | Metastasis to pelvic/para-aortic lymph nodes or to both IIIC1: Metastasis to pelvic lymph nodes IIIC1i: Micrometastasis IIIC1ii: Macrometastasis IIIC2 Metastasis to the para-aortic lymph nodes up to level of renal vessels, with or without metastasis to pelvic lymph nodes IIIC2i: Micrometastasis IIIC2ii: Macrometastasis |
Stage IV | Spread to bladder mucosa and/or to intestinal mucosa and/or evidence of distance metastasis |
IVA | Invasion of bladder mucosa and/or intestinal/bowel mucosa |
IVB | Abdominal peritoneal metastasis beyond pelvis |
IVC | Distant metastasis, which includes metastasis to any extra- or intra-abdominal lymph nodes above the renal vessels, lungs, liver, brain, or bone |
Abbreviations: FIGO, International Federation of Gynecology and Obstetrics; LVSI, lymphovascular space involvement.