Figure 4.
Transcriptomic comparison of WHOnew, MD-WHOest, MP-WHOest, and healthy controls. (A) Principal component analysis of all included WHOnew, MD-WHOest, MP-WHOest, and healthy control samples. (B) Unsupervised clustering of 33 WHOnew and 193 MD- and MP-WHOest cases. (C) Overlap between significantly differentially expressed genes in the WHOnew, MD-WHOest, and MP-WHOest cohorts compared against healthy controls. (D) Volcano plot depicting differential gene expression between the WHOnew and MD-WHOest cohorts. The dotted line denotes the FDR cutoff at 0.05. (E) Normalized enrichment score of the 19 significantly enriched hallmark gene sets highlighted in dark blue. FDR, false discovery rate; logFC, log fold change; PC, principal component; NES, normalized enrichment score.