Table 4b. The cytotoxicity and bone marrow recovery between patients with wild-type and variant genotypes concerning the CYP2B6*9 (G516T) variant following cyclophosphamide chemotherapy.
| Parameter | GG | GT + TT | p-value | |
|---|---|---|---|---|
| n = 40 | n = 51 | |||
| Hemoglobin (g/dl) | mean ± SD | 11.1 ± 0.93 | 10.9 ± 1.03 | =0.34 |
| Neutrophils (×109/L) | mean ± SD | 2.48 ± 1.29 | 3.49 ± 1.14 | <0.001* |
| Platelets (×109/L) | median (range) | 131 (60–220) | 155 (50–211) | =0.14 |
| Adverse events♦ | Absent | 16 (40%) | 45 (88%) | <0.001* |
| Present | 24 (60%) | 6 (12%) | ||
Note: Student-t test, Mann-Whitney U test and Chi-square test were applied. *: statistically significant (if p < 0.05), Adverse events ♦: febrile fever, admission to hospital >3 days, vomiting, diarrhea, or infections.