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. 2024 Mar 13;627(8005):854–864. doi: 10.1038/s41586-024-07171-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Plot of average silhouette scores reveals that the statistically optimal number of cellular communities is thirteen. b, ~250,000 cell zones were grouped into specific cellular communities as shown by UMAP and colored by community. c, Spatial mapping of these CCs onto three different sections of the 13 p.c.w. (post conception weeks) heart shows the reproducibility of CCs corresponding to specific anatomic cardiac structures. The distribution of (d) cell zone complexity and (e) purity is displayed both spatially for replicate sections of 13 p.c.w. hearts (zone complexity/purity maps) and quantitatively in violin plots. The center white dot represents the median, the bold black line represents the interquartile range, and the edges define minima and maxima of the distribution. AVC, atrioventricular canal; AVN, atrioventricular node; IFT, inflow tract; IVS, interventricular septum; LA, left atrium; LV, left ventricle; Mus. Valve Leaf., muscular valve leaflet; MV, mitral valve; OFT, outflow tract; RA, right atrium; RV, right ventricle; SAN, sinoatrial node; TV, tricuspid valve; VCS, ventricular conduction system. Scale bar, 250 µm.