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. 2024 Mar 13;627(8005):854–864. doi: 10.1038/s41586-024-07171-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 11 — a, The distribution of distinct ventricular cardiac cells participating in SEMA3C/3D/6 A/6B - PLXNA2/4 interactions is shown within the left ventricular wall. Cells are colored by community and identity as indicated in Fig. 3b. b, Magnified view of boxed area in (a) reveals how these cells spatially organize in the Intermediate-LV CC. c, Neighborhood enrichment plot of Intermediate-LV CC shows that vCM-LV-Trabecular I, vCM-LV-Trabecular II, vCM-LV-Hybrid are closer to BECs than Compact vFibro. d, smFISH and imputed spatial expression (vFISH) analyses show the spatial gene expression of interacting semaphorin ligands and plexin receptors. e, Violin plot shows the level of expression (smFISH) for each of the semaphorin ligands and plexin receptors across the ventricular wall depth. The center white dot represents the median, the bold black line represents the interquartile range, and the edges define minima and maxima of the distribution. BEC, blood endothelial cell; CC cellular community; CM, cardiomyocyte; Int., intermediate; LV, left ventricle; smFISH, single molecule fluorescent in situ hybridization; vCM, ventricular cardiomyocyte; vFibro, ventricular fibroblast; vFISH, virtual fluorescent in situ hybridization. Scale bar, 250 µm.