Extended Data Fig. 12. Tcf21-creERT2;Sema3c^fl/fl knockout mice display hypertrabeculation and relatively thin compact myocardium.

a, Representative hematoxylin and eosin stained frontal sections of hearts from Tcf21-creERT2;Sema3c^fl/fl knockout mice at indicated stages show that deletion of Sema3c in Tcf21+ cells starting at E10.5 leads to a progressive cardiac ventricular wall noncompaction phenotype (i.e., hypertrabeculation and thinner compact myocardium), which continues postnatally. Scale bar, 250 µm (50 µm in inset). b, Graphs show the thickness of compact and trabecular myocardium from E12.5 to P1. N = 3 mice per condition. KO, knockout; LV, left ventricle; RV, right ventricle; WT, wildtype. Error bars are s.e.m. P values determined by one-way ANOVA.

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