Figure 4.

Protein-coding transcripts from the human genome display biased distribution in APOBEC3A/B motif representation and mutational susceptibility

The bimodal distribution of APOBEC3A/B motif representation displays higher heterogeneity by spatial clonal dynamics simulation.

(A) The number of genotypes between with and without APOBEC3A/B shows no significant difference.

(B) Heterogeneity between the two simulations with and without APOBEC3A/B shows no significant difference.

(C and D) Muller plots of simulation with and without APOBEC3A/B activity show no significant difference in heterogeneity at the final time point.

(E) The number of genotypes between uniform and bimodal distribution shows an increasing difference over time.

(F) Heterogeneity between uniform and bimodal distribution shows an increasing difference over time.

(G and H) Muller plots of simulation uniform and bimodal distribution show an increasing difference over time.