REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit polyclonal anti-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)	Cell Signaling Technology	Cat#9101S (RRID: AB_331646)
Mouse monoclonal anti-CCNB1	Santa Cruz	SC-245 (RRID: AB_627338)
Mouse monoclonal anti-beta actin	Santa Cruz	SC-47778 (RRID: AB_626632)
Rabbit monoclonal anti- Cleaved Caspase-3	Cell Signaling Technology	Cat#9664S (RRID: AB_2070042)
Chemicals, peptides, and recombinant proteins
CCR6 inhibitor	MedChem Express	Cat# HY-112701
PD0325901	Peprotech	Cat# 3911091
Critical commercial assays
Seahorse XF Glycolytic Rate Assay Kit	Agilent	Cat# 103344–100
Seahorse XF Mitochondrial Respiration Assay Kit	Agilent	Cat# 103260–100
MitoSOX™ Mitochondrial Superoxide Indicators	Invitrogen	Cat# M36008
Deposited data
Raw and analyzed RNA-seq data	This paper	GEO: GSE244730
Experimental models: Cell lines
PC-9 cells	Laboratory stocks	RRID: CVCL_B260
HCC827 cells	Laboratory stocks	RRID: CVCL_2063
Software and algorithms
ImageJ	National Institutes of Health	https://imagej.nih.gov/ij/
JuLI stage	NanoEntek	http://www.julistage.com
Seahorse XF Pro Analyzer	Agilent	https://www.agilent.com
R version 4.2.3	R Development Core Team	https://www.r-project.org/
FASTQC version 0.11.9	Babraham Bioinformatics Group	https://www.bioinformatics.babraham.ac.uk/projects/fastqc/
TrimGalore version 0.6.6	Babraham Bioinformatics Group	https://www.bioinformatics.babraham.ac.uk/projects/trim_galore/
STAR version 2.7.9a	Alexander Dobin et al.69	https://github.com/alexdobin/STAR
RSEM version 1.3.3	Bo Li et al.70	https://github.com/deweylab/RSEM
GraphPad Prism 9 version.4.2.3	GraphPad Software, Inc.	https://www.graphpad.com/features
FlowJo	BD Biosciences	https://www.bdbiosciences.com/en-us/products/software/flowjo-v10-software
Other
DepMap portal	Open-source	https://depmap.org/portal/
GDSC	Open-source	https://www.cancerrxgene.org
TCGA	Open-source	https://gdc.cancer.gov/about-data/publications/pancanatlas
cBioPortal	Open-source	https://www.cbioportal.org
MsigDB	Open-source	https://www.gsea-msigdb.org/gsea/msigdb
DrugBank	Open-source	https://go.drugbank.com