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. 2024 Mar 14;15:1342647. doi: 10.3389/fimmu.2024.1342647

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Copyright © 2024 Li, Zhang, Niu, Wu, Deng and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The scRNA-seq analyses demonstrated the comprehensive immune landscape variations of TME after MSA-2 administration. (A) The cell clustering distribution of TME through secondary scRNA-seq analysis. (B) The alternations of cell distributions in TME of a breast cold tumor model between the control group (CTL) and MSA-2 treatment group. (C) The detailed cell proportions between CTL and MSA-2 treatment group. (D) The specific biomarkers of each component within TME. The signaling variations of T cells (E), NK cells (F), cDCs (G), and macrophages (H).