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. 2024 Mar 14;14:1305518. doi: 10.3389/fonc.2024.1305518

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Copyright © 2024 Gulyás, Pinczés, Mátyus, Végh, Bedekovics, Tóth, Barna, Hunya, Szabó, Gazdag, Illés and Magyari

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Abnormal contrast uptake (arrows) on ¹⁸FDG-PET/CT image in the lower extremities (SUVmax 4.4-7.2) (A). Control ¹⁸FDG-PET/CT image after interferon alpha administration shows refractory disease (SUVmax 7.4-9.4) (B). Control 18FDG-PET/CT image after 3 months of cobimetinib administration shows disease regression (SUVmax 3.2) (C). Pulmonary tissue sample shows fibrosis with foamy histiocytes and lymphoplasmocytic infiltration (arrow) (hematoxylin eosin x100) (D). Pulmonary tissue sample shows fibrosis with foamy histiocytes (arrow) and lymphoplasmocytic infiltration (hematoxylin eosin x400) (E).