Table 3.
KEGG pathway enrichment analysis of potential targets modulated by the phytocompounds from K.pinnata.
| KEGG ID | Pathway description | False discovery rate | Matching proteins in your network (labels) | Gene count |
|---|---|---|---|---|
| hsa03320 | PPAR signalling pathway | 2.11E-07 | FABP4,FABP2,FABP1,FABP5,PPARD,MMP1,SCD,FABP3,PPARA,NR1H3 | 10 |
| hsa04080 | Neuroactive ligand-receptor interaction | 2.98E-06 | ADORA3,GRIN2D,ADRA2A,GRIN2C,F2,GRIN2A,ADORA1,CNR1,GABBR1,CHRM5,DRD1,AGTR1,LTB4R2,TRPV1,GRIN2B,ADORA2A | 16 |
| hsa04151 | PI3K-Akt signalling pathway | 5.92E-06 | IL2,KDR,FGF2,CDK6,CDK2,EGFR,MET,GSK3B,HSP90AB1,TLR4,ITGB1,RELA,PIK3CG,VEGFC,FGF1,IGF1R | 16 |
| hsa00790 | Folate biosynthesis | 6.93E-06 | AKR1B1,CBR1,ALPI,AKR1B10,ALPL,AKR1C3 | 6 |
| hsa04015 | Rap1 signalling pathway | 1.21E-05 | KDR,FGF2,EGFR,MET,GRIN2A,CNR1,ITGB1,GRIN2B,ADORA2A,VEGFC,FGF1,IGF1R | 12 |
| hsa04933 | AGE-RAGE signalling pathway in diabetic complications | 8.40E-05 | MMP2,NOX4,F3,PIM1,RELA,TNF,AGTR1,VEGFC | 8 |
| hsa04931 | Insulin resistance | 0.00014 | GSK3B,PTPN1,RPS6KA3,RELA,PPARA,TNF,NR1H3,NR1H2 | 8 |
| hsa04010 | MAPK signalling pathway | 0.00026 | CDC25B,KDR,FGF2,EGFR,PTPN7,MET,RPS6KA3,RELA,TNF,VEGFC,FGF1,IGF1R | 12 |
| hsa04213 | Longevity regulating pathway - multiple species | 0.0146 | HDAC1,HDAC2,CRYAB,IGF1R | 4 |
| hsa00500 | Starch and sucrose metabolism | 0.018 | SI,MGAM2,AMY2A | 3 |
| hsa04114 | Oocyte meiosis | 0.0248 | CDK2,AR,RPS6KA3,CDK1,IGF1R | 5 |
| hsa04012 | ErbB signalling pathway | 0.0309 | EGFR,GSK3B,ABL1,ABL2 | 4 |
| hsa04973 | Carbohydrate digestion and absorption | 0.0354 | SI,MGAM2,AMY2A | 3 |