TABLE 1.
Swine survival, viremia, and fever response following infection with Malawi Lil-20/1, Δ8DR, and 8-DR.R
| Virus | Days to death | Fever, days to onset | Viremia (no. of viremic animals)a
|
|||||
|---|---|---|---|---|---|---|---|---|
| Days to onset | Mean titer log10/TCID50/ml at dpi:
|
|||||||
| 1 | 3 | 5 | 7 | 9 | ||||
| Expt 1 (n = 3) | ||||||||
| Malawi | ||||||||
| Lil-20/1 | 7.0 ± 0.0 | 3.0 ± 0.0 | 3.0 ± 0.0 | Negative | 7.4 ± 0.4 (3) | 8.8 ± 0.3 (3) | ||
| Δ8-DR | 8.3 ± 0.3 | 4.3 ± 0.9 | 5.0 ± 0.0 | Negative | Negative | 4.1 ± 0.4(a) (3) | 6.1 ± 0.8 (3) | 8.3 ± 0.0 (1) |
| Expt 2 (n = 5) | ||||||||
| 8-DR.R | 9.6 ± 0.8 | 2.8 ± 0.6 | 2.2 ± 0.5 | 3.1 ± 0.4 (2) | 4.9 ± 0.5 (5) | 6.9 ± 0.1 (5) | 7.3 ± 0.1 (4) | 7.0 ± 0.5 (2) |
| Δ8-DR | 10.3 ± 0.3 | 3.4 ± 0.7 | 6.2 ± 0.5(b) | Negative | Negative | 3.4 ± 0.1(c) (2) | 4.6 ± 0.2(c) (5) | 5.6 ± 0.3(d) (4) |
a
Values significantly different from those for Malawi Lil-20/1 and 8-DR.R group are indicated as follows: (a) P = 0.008; (b) P = 0.001; (c) P = 0.0001; (d) P = 0.04.