Table 3.
MUpro and ConSurf servers are used to assess the protein stability and evolutionary conservation profile of high-risk nsSNPs in SOD1
| MUpro | Consurf | ||||
|---|---|---|---|---|---|
| Amino acid change | DDG value Kcal/mol | Stability | Conservation score | Burried/exposed | Grade based on conservation scale |
| I113T | – 1.6569 | Decrease | – 0.136 | Burried | 5 |
| G38R | – 1.065613 | Decrease | – 0.613 | Exposed | 7 |
| G42D | – 0.9597 | Decrease | – 0.784 | Exposed | 8 |
| G86R | – 0.7265 | Decrease | – 0.851 | Burried | 8 |
| G94R | – 0.466 | Decrease | – 0.928 | Exposed | 8 |
| G94C | – 0.4873 | Decrease | – 0.928 | Exposed | 8 |
| I114T | – 2.083822 | Decrease | 0.044 | Exposed | 5 |
| C7F | – 0.2014 | Decrease | – 0.362 | Burried | 6 |
| I152T | – 1.9609484 | Decrease | 0.528 | Exposed | 4 |
| G13R | – 0.2511 | Decrease | 0.191 | Exposed | 5 |
| F46C | – 1.7934 | Decrease | – 0.5 | Burried | 7 |