Table 2.

Immune profiles in healthy controls (HC) and patients with major dysmood disorder (MDMD) with very severe physiosomatic symptoms and immune profiles (Severe MDMD) and MDMD patients with milder physiosomatic and immune scores (Milder MDMD).

Variables (z scores)	HC n = 32	Less severe MDMD n = 29	Severe MDMD n = 35	F/X2	df	P
Classical macrophage M1	− 0.604 ± 0.918 b,c	0.005 ± 0.902 a,c	0.548 ± 0.839 a,b	14.16	2/93	< 0.001
Alternative macrophage M2	− 0.479 ± 0.851 b,c	0.043 ± 0.914 a	0.402 ± 1.030 a	7.42	2/93	0.001
zM1–zM2	0.124 ± 0.724	− 0.039 ± 0.489	0.146 ± 0.581	1.73	2/93	0.184
Thelper (Th)-1	− 0.592 ± 1.086 b,c	0.017 ± 0.695 a,c	0.527 ± 0.841 a,b	13.17	2/93	< 0.001
Th-2	− 0.398 ± 0.975 c	− 0.150 ± 0.844 c	0.489 ± 0.961 a,b	8.12	2/93	< 0.001
zTh-1–zTh-2	− 0.194 ± 0.605 b	0.168 ± 0.484 a	0.0380 ± 0.454	3.86	2/93	0.025
Th-17	− 0.392 ± 1.305 c	− 0.098 ± 0.700 c	0.440 ± 0.696 a,b	6.71	2/93	0.002
IRS	− 0.632 ± 1.051 b,c	0.002 ± 0.679 a,c	0.577 ± 0.829 a,b	16.10	2/93	< 0.001
CIRS	− 0.564 ± 0.933 b,c	− 0.055 ± 0.629 a,c	0.561 ± 1.023 a,b	13.43	2/93	< 0.001
zIRS–zCIRS	− 0.163 ± 1.002	0.136 ± 0.977	0.037 ± 1.025	0.71	2/93	0.494
Immu-NT	− 0.575 ± 1.108 b,c	− 0.043 ± 0.665 a,c	0.560 ± 0.820 a,b	13.71	2/93	< 0.001

All results are shown as mean ± SD. F: results of analysis of variance.

IRS immune-inflammatory response system, CIRS compensatory immunoregulatory system, Immu-NT immune-associated neurotoxicity.