Table 5.

Results of multiple regression analysis with symptom domains as dependent variables and cytokines/chemokines/growth factors, adverse childhood experiences (ACEs) and negative life events (NLEs) as explanatory variables.

Dependent variables	Explanatory variables	Coefficients of input variables			Model statistics
		β	t	p	R2	F	df	p
#1. Pure depression	Model				0.52	24.63	Apr-91	< 0.001
	IL-16	0.523	5.67	< 0.001
	CCL3	− 0.313	− 3.88	< 0.001
	ACE + NLEs	0.219	2.43	0.017
	SCGF	0.171	2.19	0.031
#2 Pure anxiety	Model				0.503	23.03	Apr-91	< 0.001
	IL-16	0.509	5.43	< 0.001
	ACE + NLEs	0.281	3.1	0.003
	CCL3	− 0.222	− 2.81	0.006
	Education	− 0.149	− 1.99	0.049
#2. Physiosomatic symptoms	Model				0.62	24.24	Jun-89	< 0.001
	IL-16	0.709	6.68	< 0.001
	ACE + NLEs	0.225	2.68	0.009
	CCL3	− 0.321	− 3.87	< 0.001
	Sex	0.255	3.55	0.001
	sIL-1RA	− 0.231	− 2.53	0.013
	IL-8	0.19	2.32	0.023
#4. Pure FF	Model				0.498	22.58	Apr-91	< 0.001
	IL-16	0.715	5.5	< 0.0010.00.002
	CIRS	− 0.365	− 3.18	0.008
	ACE + NLEs	0.248	2.7	0.035
	Sex	0.164	2.14
#5. Melancholia	Model				0.568	40.36	Mar-92	< 0.001
	IL-16	0.32	3.27	0.002
	ACEQ24710	0.31	3.89	< 0.001
	SCGF	0.247	2.8	0.006
#6. GIS	Model				0.494	17.55	May-90	< 0.001
	CCL3	− 0.431	− 4.6	< 0.001
	CCL11	0.316	3.83	< 0.001
	ACE + NLEs	0.202	2.41	0.018
	M-CSF	0.35	3.97	< 0.001
	IL-8	0.238	2.82	0.006
	CXCL1	0.218	2.46	0.016
#7. Insomnia	Model				0.57	30.21	Apr-91	< 0.001
	IL-16	0.568	4.52	< 0.001
	ACE + NLEs	0.208	2.49	0.015
	sIL-1RA	− 0.246	− 2.59	0.011
	SCGF	0.234	2.41	0.018

IL interleukin, SCGF stem cell growth factor, sIL-1RA soluble IL-1 receptor antagonist, sex males = 1, females = 0, CIRS compensatory immunoregulatory system, TRAIL tumor necrosis factor-related apoptosis-inducing ligand.