Table 3.
Top 20 S-Multixcan results after correction of multiple testing
| Phenotypea | T_i_bestb | Gene | P_i_bestc | FDR.adjust Pd |
|---|---|---|---|---|
| EVA_Total | Brain_Cortex | HSD3B7 | 1.71E-03 | 9.55E-20 |
| ELD_Total | Brain_Hypothalamus | RP11-497H16.2 | 9.72E-06 | 4.55E-14 |
| EVK_Total | Brain_Caudate_basal_ganglia | HSD3B7 | 5.12E-03 | 3.68E-13 |
| CVB_Total | Brain_Cerebellar_Hemisphere | SEMA6C | 3.77E-04 | 2.77E-12 |
| CDICT_Total | Brain_Caudate_basal_ganglia | LINC00638 | 4.47E-03 | 6.79E-12 |
| CVA_Total | Brain_Nucleus_accumbens_basal_ganglia | PIF1 | 8.76E-03 | 6.91E-12 |
| EVB_Total | Brain_Cortex | HSD3B7 | 1.16E-02 | 1.69E-11 |
| CWR_Norm | Brain_Hypothalamus | RP11-497H16.2 | 4.14E-04 | 9.80E-11 |
| CWR_Total | Brain_Hypothalamus | RP11-497H16.2 | 9.01E-04 | 1.66E-09 |
| CCR_Total | Brain_Hypothalamus | RP11-497H16.2 | 3.53E-05 | 2.96E-09 |
| EVD_Total | Brain_Caudate_basal_ganglia | HSD3B7 | 8.07E-03 | 7.52E-09 |
| EWR_Total | Brain_Cortex | HSD3B7 | 1.40E-02 | 1.71E-08 |
| ELRAN_Mean | Brain_Hypothalamus | RP11-497H16.2 | 1.93E-04 | 3.30E-08 |
| ELRAN_Mean | Brain_Nucleus_accumbens_basal_ganglia | BAK1P1 | 3.91E-03 | 4.34E-08 |
| EDRAN_Mean | Brain_Nucleus_accumbens_basal_ganglia | ZNF565 | 2.00E-02 | 5.33E-08 |
| EDRAN_Mean | Brain_Cortex | HSD3B7 | 2.01E-02 | 2.34E-07 |
| EDICT_Total | Brain_Anterior_cingulate_cortex_BA24 | MYO6 | 3.35E-04 | 3.77E-07 |
| COM_Score | Brain_Cerebellum | RBM8A | 8.38E-02 | 4.39E-07 |
| CLD_Total | Brain_Caudate_basal_ganglia | OXCT2P1 | 3.87E-04 | 6.56E-07 |
| ELRAN_Mean | Brain_Nucleus_accumbens_basal_ganglia | CYP2E1 | 7.51E-03 | 6.70E-07 |
aPlease refer to Table 10 for abbreviations of the phenotype.
bT_i_Best: name of best single-tissue S-Predixcan association.
cP_i_Best: best p-value of single tissue S-Predixcan association.
dFDR-adjust P: FDR-adjusted p-value of the overall p-value output by S-Multixcan. FDR was calculated by the R program p.adjust using the Benjamini-Hochberg procedure (BH).