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. 2024 Mar 27;9:26. doi: 10.1038/s41539-024-00229-7

Table 9.

Testing for genetic dependence with the GenLang sample (Eising et al.), using full GWAS summary statistics and the Hoeffding’s test of independence (results with FDR adjusted p < 0.1 are shown)

Trait A Trait B Scaled statistic p-value FDR-adjusted p
BDS_Total Word Reading 1.663 2.04E-02 4.63E-02
CDC_Total Spelling 2.696 4.24E-03 8.75E-02
CLD_Total Word Reading 2.406 6.55E-03 2.02E-02
CVA_Total Word Reading 5.853 4.31E-05 4.88E-04
CVB_Total Word Reading 2.247 8.34E-03 2.36E-02
CVK_Total Word Reading 1.852 1.53E-02 3.70E-02
CWR_Total Word Reading 1.122 4.84E-02 8.65E-02
DS_Total Word Reading 6.382 2.03E-05 4.47E-04
EDRAN_Mean Word Reading 1.216 4.15E-02 7.85E-02
EIS_Total Word Reading 6.199 2.63E-05 4.47E-04
ELD_Total Word Reading 4.428 3.33E-04 2.83E-03
ELRAN_Mean Word Reading 2.665 4.44E-03 1.68E-02
ELRAN_Mean Spelling 2.566 5.14E-03 8.75E-02
EVA_Total Word Reading 1.228 4.07E-02 7.85E-02
EVD_Total Word Reading 2.975 2.79E-03 1.36E-02
EWR_Total Word Reading 2.137 9.85E-03 2.58E-02
MS_Total Word Reading 3.298 1.74E-03 9.84E-03
PureC_Total Word Reading 1.038 5.55E-02 9.43E-02
RC_MC Word Reading 2.774 3.77E-03 1.60E-02
RC_OE Word Reading 2.433 6.29E-03 2.02E-02
RC_Total Word Reading 3.786 8.48E-04 5.77E-03
WO_Total Word Reading 1.460 2.81E-02 5.98E-02
WO_Total Phoneme awareness 2.967 2.83E-03 9.62E-02

Trait A comes from the Hong Kong sample, while trait B is from the study by Eising et al. Scaled statistic: the test statistic rescaled for a standard null distribution (please refer to the R package “independence” for details). FDR adjusted-p < 0.05 are in bold and those between 0.05 and 0.1 are in italics. FDR adjustment was performed with stratification by trait B.