Table 9.
Testing for genetic dependence with the GenLang sample (Eising et al.), using full GWAS summary statistics and the Hoeffding’s test of independence (results with FDR adjusted p < 0.1 are shown)
| Trait A | Trait B | Scaled statistic | p-value | FDR-adjusted p |
|---|---|---|---|---|
| BDS_Total | Word Reading | 1.663 | 2.04E-02 | 4.63E-02 |
| CDC_Total | Spelling | 2.696 | 4.24E-03 | 8.75E-02 |
| CLD_Total | Word Reading | 2.406 | 6.55E-03 | 2.02E-02 |
| CVA_Total | Word Reading | 5.853 | 4.31E-05 | 4.88E-04 |
| CVB_Total | Word Reading | 2.247 | 8.34E-03 | 2.36E-02 |
| CVK_Total | Word Reading | 1.852 | 1.53E-02 | 3.70E-02 |
| CWR_Total | Word Reading | 1.122 | 4.84E-02 | 8.65E-02 |
| DS_Total | Word Reading | 6.382 | 2.03E-05 | 4.47E-04 |
| EDRAN_Mean | Word Reading | 1.216 | 4.15E-02 | 7.85E-02 |
| EIS_Total | Word Reading | 6.199 | 2.63E-05 | 4.47E-04 |
| ELD_Total | Word Reading | 4.428 | 3.33E-04 | 2.83E-03 |
| ELRAN_Mean | Word Reading | 2.665 | 4.44E-03 | 1.68E-02 |
| ELRAN_Mean | Spelling | 2.566 | 5.14E-03 | 8.75E-02 |
| EVA_Total | Word Reading | 1.228 | 4.07E-02 | 7.85E-02 |
| EVD_Total | Word Reading | 2.975 | 2.79E-03 | 1.36E-02 |
| EWR_Total | Word Reading | 2.137 | 9.85E-03 | 2.58E-02 |
| MS_Total | Word Reading | 3.298 | 1.74E-03 | 9.84E-03 |
| PureC_Total | Word Reading | 1.038 | 5.55E-02 | 9.43E-02 |
| RC_MC | Word Reading | 2.774 | 3.77E-03 | 1.60E-02 |
| RC_OE | Word Reading | 2.433 | 6.29E-03 | 2.02E-02 |
| RC_Total | Word Reading | 3.786 | 8.48E-04 | 5.77E-03 |
| WO_Total | Word Reading | 1.460 | 2.81E-02 | 5.98E-02 |
| WO_Total | Phoneme awareness | 2.967 | 2.83E-03 | 9.62E-02 |
Trait A comes from the Hong Kong sample, while trait B is from the study by Eising et al. Scaled statistic: the test statistic rescaled for a standard null distribution (please refer to the R package “independence” for details). FDR adjusted-p < 0.05 are in bold and those between 0.05 and 0.1 are in italics. FDR adjustment was performed with stratification by trait B.