Table 1.
Summary of uncovered MT-binding modules in MIPs across C. reinhardtii and mammals
| Domain or module | MIP | C. Reinhardtii paralogs | H. Sapiens paralogs |
|---|---|---|---|
| DM10 | FAP67, RIB72 | FAP67, RIB72, XP_001691061, DM10DCP | EFHC1, EFHC2, NME7, CAPS2 |
| Mn repeat (only) | FAP363 | FAP257, FAP203, FAP236 | MAP6, MAP6D1, SAXO1, SAXO2, TEX45 (SAXO5), TEX26, C2ORF73, MDM1 |
| FAP273 | - | TEX36, TEX37 (SPMIP9), C3ORF84, C1ORF100 (SPMIP3), SMRP1 (SPMIP6) | |
| RIB21 | - | ||
| FAP166 | - | ||
| Mn + PYG | FAP129 | - | - |
| NWE + Mn | FAP95 | FAP68, FAP95, FAP143 FAP107 | C9ORF135 (CFAP95) |
| FAP107 | C1ORF158 (CFAP107) | ||
| FAP143 | SPAG8 | ||
| FAP68 | C11ORF1 (CFAP68) | ||
| NWE only | FAP161 | FAP161 | CFAP161 |
| PYG | FAP129 | FAP129, FAP252, FAP222 | FAM166A (CIMIP2B), FAM166B (CIMIP2B), FAM166C (CIMIP2C), C10ORF82 (SPMIP5), SPATA48 (SPMIP7) |
| FAP252 | |||
| FAP222 | |||
| SNYG (Divergent Mn repeat + ass. helix) | FAP85 | FAP90, FAP85, FAM183A, FAP144, FAP182 | PIERCE1, PIERCE2, C5ORF49 (CFAP90), FAM183A (CFAP144), C20ORF85 (CIMIP1), C2ORF50, ATP6V1FNB (SPMIP1), TEX49 (SPMIP11) |
| FAP182 | |||
| FAP90 | |||
| GFG repeat | FAP77 | FAP77, FAP21 | EFHB, CFAP77 |
| FAP21 | |||
| ELLEn | FAP53 | FAP53, FAP141 | CFAP53 |
| CFAP141 | |||
| FAP141 | |||
| TCHP |
Summary of uncovered MT-binding modules in MIPs across C. reinhardtii and mammals. Proteins are grouped according to the two known and five novel protein modules families identified in this study: DM10 domain, Mn, PYG, and GFG repeats, and NWE, SNYG, and ELLEn modules. The identified MIP modules, except for the ELLEn module, show preference for the MT inner surface.