TABLE 2.

Comparison of error rates at specific hot spots

Mutation type and position	Wild-type RT		Q151M RT		VILYM RT
	No. of errors	Error rate	No. of errors	Error rate	No. of errors	Error rate
Base substitutions
−36	20	1/580	17	1/670	7a	1/2,900
40	0	CDd	5a	1/2,300	0	CD
42	0	CD	10b	1/1,100	0	CD
89	13	1/880	5	1/2,300	1b	1/21,000
90	6	1/1,900	13c	1/870	7	1/2,900
144	0	CD	6a	1/1,800	1	1/21,000
Frameshifts
132–136	1	1/47,000	6c	1/7,600	1	1/83,000
137–139	8	1/4,700	1a	1/34,000	5	1/12,000
All	123	1/22,000	104	1/25,000	106	1/44,000

^aP < 0.05 by Fisher’s exact test when compared to errors made by the wild-type enzyme. 

^bP ≤ 0.002 by Fisher’s exact test when compared to errors made by the wild-type enzyme. 

^cP < 0.06 by Fisher’s exact test when compared to errors made by the wild type enzyme. 

^dCD, Cannot be determined.