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. 2024 Mar 27;11:316. doi: 10.1038/s41597-024-03152-z

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Functional analysis of differentially expressed genes across the different organs in each immune cell type. (a) Barplot showing the unique regulons in each organ (y axis) and the percentage of the detected immune cell subpopulations showing the regulons in each organ (x axis). (b) Network of the regulons (blue) and the genes associated with the gene-signature (red). (c) Barplot showing the shared pathways in the GSEA (y axis) per immune cell type and in each organ and the enrichment score values (x axis). (d) Analysis of the TNFA signaling pathway via NFkB in each immune cell type showing the expression of the TNF and NFkB family members, the target genes and the target cytokines.