Table 1.
Clinical characteristics of healthy subjects and patients with type 2 diabetes.
| Characteristics | Healthy subjects (n = 413) | Diabetics (n = 292) | U value | P value |
|---|---|---|---|---|
| Age (year) | 43 ± 12 | 57 ± 11 | 22,292 | < 0.0001 |
| Male (%) | 206 (49.9) | 143 (49.0) | NA | 0.81 |
| BMI | 22.1 ± 3.3 | 26.1 ± 5.1 | 29,797 | < 0.0001 |
| Systolic BP (mmHg) | 120 ± 15 | 138 ± 16 | 23,709 | < 0.0001 |
| Diastolic BP (mmHg) | 72 ± 11 | 81 ± 11 | 32,172 | < 0.0001 |
| HbA1c (%) | 5.5 ± 0.3 | 7.5 ± 1.2 | 2365 | < 0.0001 |
| HDL-C (mg/dL) | 67 ± 17 | 52 ± 12 | 92,155 | < 0.0001 |
| Non-HDL-C (mg/dL) | 141 ± 35 | 134 ± 33 | 67,391 | 0.008 |
| Uric acid (mg/dL) | 4.9 ± 1.3 | 5.1 ± 1.2 | 53,489 | 0.011 |
| UACR (mg/gCr) | 4.5 (3.4, 7.3) | 18.1 (7.1, 58.9) | 92,155 | < 0.0001 |
| eGFR-Cr (mL/min/1.73 m2) | 82 ± 13 | 85 ± 19 | 58,505 | 0.50 |
| eGFR-CysC (mL/min/1.73 m2) | 110 ± 19 | 97 ± 23 | 81,948 | < 0.0001 |
| TNFR1 (pg/mL) | 992 (873, 1126) | 1357 (1133, 1646) | 19,703 | < 0.0001 |
| TNFR2 (pg/mL) | 1951 (1717, 2218) | 2904 (2505, 3391) | 14,127 | < 0.0001 |
BMI body mass index, BP blood pressure, Cr creatinine, CysC cystatin C, eGFR estimated glomerular filtration rate, HbA1c glycated hemoglobin, HDL-C high-density-lipoprotein cholesterol, NA not applicable, TNF tumor necrosis factor, TNFR TNF receptor, UACR urinary albumin-to-creatinine ratio.