Fig. 2. Cryo-EM structures of gS87 and pS87 fibrils.

The density maps of the gS87 (a) and pS87 (b) fibril are colored in light-blue and pink, respectively. Fibril parameters including half-pitch, fibril width, twist angle, and helical rise are marked. Cross-section view for the density maps with a built-in structure model of gS87 (c) and pS87 (d) α-syn. Topology diagrams are shown at the bottom right. e Zoom-in views of the GlcNAc molecules in the electron density from (c) are shown. Views of three layers of gS87 (f) and pS87 (g) α-syn fibrils are shown in the cartoon. The β-strands of the fibril structures are numbered and labeled accordingly with the fibril axis indicated.