Table 2.

YBX1 expression and biological sex survival analysis in 15 cancer cohorts.

Cancer cohort	Sample size (sex division)	YBX1 expression profile (mean, min–max values)	YBX1 expression significance level	YBX1 hazard ratio* (95% confidence)
Significant after Benjamini–Hochberg procedure for multiple comparisons
Breast cancer	N = 4929 (m = 0, f = 4929)	GeneChip (9370, 96–33945)	$p<2\times {10}^{-16}$	1.049 (1.039–1.059)
Liver cancer	N = 370 (m = 249, f = 141)	mRNA sequence (6649, 1591–26649)	$p=1.45\times {10}^{-11}$	1.145 (1.110–1.191)
Lung cancer	N = 1814 (m = 1100, f = 714)	GeneChip (10975, 173–33991)	$p=2.41\times {10}^{-6}$	1.038 (1.022–1.054)
Renal papilloma	N = 287 (m = 211, f = 76)	mRNA sequence (7743, 1501–23551)	$p=9.50\times {10}^{-6}$	1.287 (1.151–1.439)
Uterine cancer	N = 542 (m = 0, f = 542)	mRNA sequence (13243, 436–44756)	$p=0.00228$	1.051 (1.018–1.084)
Sarcoma	N = 259 (m = 118, f = 141)	mRNA sequence (14586, 3929–46500)	$p=0.00359$	1.089 (1.028–1.154)
Non-significant after Benjamini–Hochberg procedure for multiple comparisons
Stomach cancer	N = 371 (m = 238, f = 133)	mRNA sequence (12902, 3259–29802)	$p=0.0262$	0.994 (0.898–0.993)
Ovarian cancer	N = 1435 (m = 0, f = 1435)	GeneChip (15042, 170–43850)	$p=0.0626$	1.009 (0.999–1.020)
Cervical cancer	N = 304 (m = 0, f = 304)	mRNA sequence (13757, 2707–40652)	$p=0.115$	1.041 (0.990–1.094)
Bladder cancer	N = 406 (m = 298, f = 108)	mRNA sequence (13457, 1223–192954)	$p=0.134$	1.007 (0.998–1.016)
Renal clear cell	N = 530 (m = 344, f = 186)	mRNA sequence (7975, 861–19403)	$p=0.156$	1.063 (0.977–1.157)
Rectal cancer	N = 165 (m = 90, f = 75)	mRNA sequence (14727, 4704–31516)	$p=0.203$	0.923 (0.816–1.044)
Pancreatic cancer	N = 177 (m = 97, f = 80)	mRNA sequence (8027, 2463–38335)	$p=0.475$	1.019 (0.967–1.074)
Gastric cancer	N = 780 (m = 544, f = 236)	GeneChip (12443, 3167–25195)	$p=0.882$	1.003 (0.968–1.039)
Head and neck cancer	N = 499 (m = 366, f = 133)	mRNA sequence (13105, 3534–56844)	$p=0.976$	1.000 (0.971–1.031)

*Hazard ratios are given per 1000 units of gene expression Quoted p-values and hazard ratios refer to YB-1 expression. Direct sex effects did not reach significance threshold and are not included here.