TABLE 2.
Correlations of sequence variations in the H proteins from vaccine and wild-type strains of measles virus and their ability to grow in Vero monkey kidney or B95-8 marmoset B-cell lines
| Virus | Amino acid at positionc:
|
Cytopathic effectd in:
|
|||
|---|---|---|---|---|---|
| 451 | 481 | 416 | B95-8 | Vero | |
| Vaccine strainsa | V | Y | D | + | + |
| Edmonston (Vero cell adapted) | V | Y | D | + | + |
| Group 1 wild typeb (China 93-5) | V | N | D | + | − |
| Group 2 wild typeb (Montefiore 89, Chicago-1) | V | N | N | + | − |
| Group 3 wild typeb (Colorado 1994) | V | N | N | + | − |
| Group 4 wild typeb (New Jersey 94) | V | N | D | + | − |
| Group 5 wild typeb (Tennessee) | K | N | D | + | − |
| Group 8 wild typeb (China 93-1) | V | N | D | + | − |
a
Moraten, Rubeovax, Zagreb, Schwarz, and AIK-C vaccine strains were tested.
b
All wild-type viruses were initially isolated with B95-8 cells.
c
Predicted amino acids in the H protein including the potential glycosylation site at residue 416.
d
B95-8 and Vero cells were infected and examined for the presence (+) or absence (−) of cytopathic effect.