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. 2023 Dec 13;4(4):100452. doi: 10.1016/j.xops.2023.100452

Figure 5.

Figure 5

Efficacy of antibacterial treatment. A, B, The colony-forming units (CFU) per cornea were determined by dilution plating. The onset group was evaluated at 16 hours postinfection, and before treatment. The other groups had 16 hours of untreated infection, followed by 8 hours of treatment as indicated. Asterisks indicated significant differences from the saline group by analysis of variance (ANOVA) with Tukey’s post-test. The pistachio lines represent a 99% and the red lines a 99.9% reduction in CFU compared with the onset. n = 6 except for onset group n ≥ 3. C, D, Images of eyes were taken before euthanasia from a fixed distance. The onset group was imaged at 16 hours postinfection, and before treatment. The other groups had 16 hours of untreated infection, followed by 8 hours of treatment as indicated. Relative infiltrate area was determined using ImageJ software. Mean and SD are shown and were compared by ANOVA and Tukey’s post-test. ∗P < 0.05; ∗∗P < 0.01; ∗∗∗P < 0.001; ∗∗∗∗P < 0.0001. Panels A, C used strain K900, and panels B, D used strain CDC1270. CEF = cefiderocol; CIP = ciprofloxacin; TOB = tobramycin; XDR = extensively drug-resistant.