Table 1.

Description of PICOTS framework

PICOTS framework	Details
Population	Facial asymmetry patients
Intervention	Orthognathic surgery
Comparison	Untreated subjects
Outcomes	Skeletal symmetry, midline discrepancies, lip canting, temporomandibular disorders, quality of life, relapse
Time	No limitation
Study type	Randomized clinical study, non-randomized clinical study (cohort study, case-control study, cross-sectional study), patient group study (case-series)

PICOTS, population, intervention, comparison, outcome, time, and study type.