Table 2.

24-h Glucose Control During OL and CL Periods in Patients Exhibiting ≥ 5% of Time in Low Glucose.

WP7 (n = 9)		WP8 (n = 28)		WP9 (n = 8)		Total (n = 45)
OL	CL	OL	CL	OL	CL	OL	CL
Diff CL-OL P value size effect		Diff CL-OL P value size effect		Diff CL-OL P value size effect		Diff CL-OL P value size effect
Time in low glucose (54 to <70 mg/dL) (%)
8.3 ± 2.3	3.3 ± 1.6	7.9 ± 2.5	3.1 ± 1.7	7.4 ± 2.1	3.5 ± 1.7	7.9 ± 2.4	3.2 ± 1.6
−5.9 [−6.8, −3.1] 0.0003 2.1		−4.9 [−5.6, −4.0] <10−4 2.1		−4.0 [−5.3, −2.7] 0.0002 1.7		−4.7 [−5.3, −4.1] <10−4 2.2
Time in very low glucose (<54 mg/dL) (%)
2.1 ± 1.1	0.8 ± 0.5	1.9 ± 1.5	0.7 ± 0.8	1.6 ± 0.9	0.9 ± 0.6	1.9 ± 1.3	0.8 ± 0.7
−1.3 [−2.1, −0.5] 0.0044 1.3		−0.9 [−1.6, −0.8] <10-4 0.9		−0.6 [−1.1, −0.3] 0.0047 0.8		−0.9 [−1.4, −0.8] <10−4 1.0
Time in range (70-180 mg/dL) (%)
65.4 ± 9.4	72.0 ± 10.6	62.5 ± 10.3	67.4 ± 8.2	63.6 ± 6.8	66.8 ± 3.8	63.3 ± 9.5	68.2 ± 8.2
6 [2.4, 10.7] 0.0066 0.5		4.7 [1.8, 8.0] 0.0028 0.5		0.2 [−0.7, 7.1] 0.0944 0.5		5.1 [2.9, 7.0] <10−4 0.5
Time in high glucose (>180 mg/dL) (%)
26.3 ± 10.1	24.7 ± 10.8	29.6 ± 10.6	29.5 ± 7.9	29 ± 7.7	29.8 ± 3.6	28.8 ± 9.9	28.6 ± 8.1
0.4 [−5.8, 2.7] 0.417 0.1		−0.3 [−3.2, 3] 0.955 0.0		0.5 [−4.2, 5.7] 0.773 0.1		−0.2 [−2.4, 1.9] 0.827 0.0
Time in very high glucose (>250 mg/dL) (%)
7.7 ± 5	6.3 ± 4.8	9.7 ± 5.9	8.5 ± 4.6	10.5 ± 5.2	8.4 ± 3.1	9.4 ± 5.6	8 ± 4.4
−1.2 [−3.6, 0.9] 0.196 0.2		−0.7 [−3, 0.7] 0.204 0.2		−2.7 [−5.2, 1.1] 0.161 0.4		−1.1[−2.6, −0.1] 0.035 0.3
Glycemia Risk Index
48.8 ±10.9	33.7 ± 12.5	52.0 ± 13.9	38.8 ± 11.4	50.8 ± 9.0	39.9 ± 6.7	51.2 ± 12.4	38.0 ± 12.9
−15.3 [−21.0, −9.1] 0.0003 1.1		−12.6 [−17.3, −9.2] <10−4 1.0		−11.0 [−15.4, −6.5] 0.0007 1.1		−13.1 [−16.0, −10.4] <10−4 1.1

Data are given as mean (SD). Differences are shown as median [95% CI]. Paired t-test and Cohen’s d test are provided.

Abbreviation: OL, open loop; CL, closed loop; CI, confidence interval.