Table 2.
HRs and 95% CIs for risk of diabetes associated with longitudinal changes in serum SHBG and T concentrations
| Sex hormone | Unadjusted HR (95% CI) | Model 1 Multivariable-adjusted* HR (95% CI) |
Model 2 Multivariable-adjusted† HR (95% CI) |
|---|---|---|---|
| SHBG (nmol/L)‡ | |||
| Baseline 5-unit increase | 0.92 (0.89–0.94) | 1.02 (0.99–1.05) | 1.02 (0.98–1.06) |
| Time-varying 5-unit increase | 0.84 (0.82–0.87) | 0.88 (0.85–0.91) | 0.91 (0.87–0.95) |
| Average change relative to baseline§ | |||
| Q1 (> −92.3 to −1.5) | 1.00 | 1.00 | 1.00 |
| Q2 (> −1.5 to −0.2) | 0.30 (0.22–0.40) | 0.16 (0.12–0.22) | 0.33 (0.23–0.48) |
| Q3 (> −0.2 to 1.3) | 0.33 (0.25–0.44) | 0.13 (0.10–0.18) | 0.37 (0.25–0.55) |
| Q4 (>1.3 to 82.0) | 0.41 (0.31–0.54) | 0.18 (0.13–0.25) | 0.43 (0.30–0.63) |
| T (ng/dL)‡ | |||
| Baseline 5-unit increase | 1.00 (0.98–1.02) | 0.99 (0.97, 1.02) | 0.99 (0.96–1.01) |
| Time-varying 5-unit increase | 1.01 (1.01–1.02) | 1.01 (1.00, 1.03) | 1.01 (1.00–1.03) |
| Average change relative to baseline§ | |||
| Q1 (−91.8 to −1.7) | 1.00 | 1.00 | 1.00 |
| Q2 (> −1.7 to −0.3) | 0.37 (0.25–0.55) | 0.32 (0.21–0.48) | 0.32 (0.21–0.48) |
| Q3 (> −0.3 to 1.0) | 0.51 (0.36–0.73) | 0.44 (0.30–0.64) | 0.41 (0.27–0.60) |
| Q4 (>1.0 to 151.7) | 0.82 (0.60–1.13) | 0.59 (0.42–0.84) | 0.54 (0.38–0.77) |
*Model 1: Multivariable models for 5-unit increase in time-varying hormone levels were adjusted for baseline age, race/ethnicity, cycle day of blood draw, study site, MT status (baseline and time-varying), BMI (baseline and time-varying), and baseline hormone level. Multivariable models for rate of change per year (quartiles) in hormone levels were adjusted for baseline age, race/ethnicity, study site, baseline menopausal transition status, baseline BMI, and baseline hormone level. SHBG and T were analyzed in separate models. †Model 2: Multivariable models in the last column were identical to those in the previous column except SHBG and T levels were analyzed in one model and E2 was added to the model. ‡SHBG data and E2 are available through visit 15, while T is available through visit 10 only. Because of this, SHBG results in the first and second columns are based on data through visit 15, whereas SHBG results in the third column, as well as all T and SHBG results, are based on data through visit 10. §P value for linear trend in quartiles of rate of change per year equal 0.001 for SHBG and 0.05 for T.