Table 1.
Demographic characteristics for the LD and DM groups, metabolic parameters before and after GLP-1RA treatment, and percentage of changes from baseline observed for each group
| Patients with FPLD | Patients with common type 2 DM | |||||
|---|---|---|---|---|---|---|
| Age (years) | 59 ± 11 | 60 ± 12 | ||||
| Female sex (%) | 79 | 71 | ||||
| Before GLP-1RA | After GLP-1RA | Change (%) | Before GLP-1RA | After GLP-1RA | Change (%) | |
| HbA1c (%) | 8.2 ± 1.4 | 7.7 ± 1.4* | −0.5 ± 0.7 | 7.6 ± 2.0 | 6.4 ± 0.9* | −1.1 ± 1.4 |
| Total cholesterol (mg/dL) | 181 ± 52 | 178 ± 63 | −7.1 ± 43.2 | 161 ± 39 | 173 ± 35 | 13.4 ± 30.1 |
| Triglycerides (mg/dL) | 334.1 ± 170 | 256 ± 81 | −16.7 ± 53.3 | 218 ± 116 | 259 ± 213 | 7.2 ± 35.6† |
| HDL cholesterol (mg/dL) | 39 ± 9 | 36 ± 8 | −2.0 ± 14.6 | 47 ± 17 | 48 ± 15 | 4.0 ± 14.6 |
| LDL cholesterol (mg/dL) | 98 ± 39 | 87 ± 46 | 3.8 ± 63.0 | 80 ± 22 | 81 ± 21 | 12 ± 32.4 |
| Fasting glucose (mg/dL) | 186 ± 64 | 166 ± 53* | −9.6 ± 18.1 | 155 ± 91 | 138 ± 51 | −2.0 ± 25.8 |
| AST (units/L) | 29 ± 14 | 29 ± 13 | 4.1 ± 24.4 | 29 ± 6 | 33 ± 22 | 14.4 ± 67 |
| ALT (units/L) | 32 ± 12 | 29 ± 10 | −2.8 ± 25.7 | 34 ± 7 | 36 ± 22 | 9.6 ± 76.0 |
| ALP (units/L) | 78 ± 25 | 69 ± 27 | −7.3 ± 13.4 | 74 ± 24 | 70 ± 22 | −1.1 ± 18.5 |
| Bilirubin (mg/dL) | 0.5 ± 0.3 | 0.5 ± 0.2 | 6.5 ± 29.3 | 0.4 ± 0.1 | 0.5 ± 0.2 | 25.6 ± 60.0 |
| BMI (kg/m2) | 33 ± 6 | 31 ± 6* | −4.1 ± 4.0 | 34 ± 5 | 34 ± 5 | −1.4 ± 4.5 |
| Weight (kg) | 95 ± 23 | 91 ± 22* | −4.0 ± 4.3 | 98 ± 20 | 96 ± 20 | −1.8 ± 4.4 |
Data are presented as mean ± SD. ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartate aminotransferase.
*P < 0.05 between before and after treatment.
†P < 0.05 comparing the LD and DM groups.