Table 1.
Mean change from baseline for summary HRQoL measures by treatment group at 1, 2, and 3 years of follow-up
| Adjustment | Outcome | Overall baseline mean (SD) | Time frame, years | Glargine | Glimepiride | Liraglutide | Sitagliptin |
|---|---|---|---|---|---|---|---|
| None (ITT) | MCS (%) | 52.54 (8.88) | 0–1 | 0.49 (0.21) | 0.49 (0.21) | 0.52 (0.21) | 0.65 (0.21) |
| 0–2 | 0.70 (0.22) | 0.88 (0.21) | 0.55 (0.21) | 0.82 (0.21) | |||
| 0–3 | NS | 0.64 (0.23) | 0.50 (0.22) | 0.59 (0.22) | |||
| PCS (%) | 46.11 (9.50) | 0–1 | 0.63 (0.20) | 0.63 (0.20) | 1.52 (0.20) | 0.86 (0.20) | |
| 0–2 | NS | NS | 0.73 (0.22) | 0.58 (0.22) | |||
| 0–3 | NS | NS | 0.51 (0.22) | NS | |||
| QWB-SA | 0.67 (0.14) | 0–1 | 0.023 (0.004) | 0.026 (0.004) | 0.028 (0.004) | 0.026 (0.004) | |
| 0–2 | 0.018 (0.004) | 0.026 (0.004) | 0.022 (0.004) | 0.024 (0.004) | |||
| 0–3 | 0.019 (0.004) | 0.026 (0.004) | 0.025 (0.004) | 0.023 (0.004) | |||
| Adjusted for weight change | MCS (%) | 52.54 (8.88) | 0–1 | 0.48 (0.22) | NS | NS | 0.63 (0.21) |
| 0–2 | 0.75 (0.22) | 0.86 (0.22) | 0.46 (0.22) | 0.81 (0.21) | |||
| 0–3 | NS | 0.62 (0.23) | 0.64 (0.24) | 0.63 (0.23) | |||
| PCS (%) | 46.11 (9.50) | 0–1 | 0.83 (0.21) | 0.85 (0.21) | 1.20 (0.23) | 0.82 (0.20) | |
| 0–2 | NS | 0.53 (0.22) | 0.50 (0.23) | 0.57 (0.22) | |||
| 0–3 | NS | 0.74 (0.23) | NS | NS | |||
| QWB-SA | 0.67 (0.14) | 0–1 | 0.024 (0.004) | 0.028 (0.004) | 0.027 (0.004) | 0.025 (0.004) | |
| 0–2 | 0.020 (0.004) | 0.027 (0.004) | 0.021 (0.004) | 0.024 (0.004) | |||
| 0–3 | 0.019 (0.004) | 0.028 (0.004) | 0.024 (0.004) | 0.020 (0.004) | |||
| Adjusted for rescue insulin | MCS (%) | 52.54 (8.88) | 0–1 | NS | NS | NS | NS |
| 0–2 | 0.52 (0.26) | 0.72 (0.25) | NS | 0.70 (0.23) | |||
| 0–3 | NS | NS | NS | NS | |||
| PCS (%) | 46.11 (9.50) | 0–1 | −0.21 (0.39) | −0.20 (0.39) | 0.70 (0.38) | 0.08 (0.37) | |
| 0–2 | NS | NS | NS | NS | |||
| 0–3 | NS | NS | NS | NS | |||
| QWB-SA | 0.67 (0.14) | 0–1 | NS | NS | 0.014 (0.007) | NS | |
| 0–2 | 0.011 (0.005) | 0.020 (0.004) | 0.016 (0.004) | 0.019 (0.004) | |||
| 0–3 | 0.014 (0.004) | 0.022 (0.004) | 0.021 (0.004) | 0.021 (0.004) |
Data are mean (SE) change unless otherwise indicated. The QWB-SA summary score ranges between 0 and 1, with higher scores indicating better quality of life. The MCS and PCS (SF-36) scores both range between 0 and 100%, with higher scores indicating better function (MCS and PCS scores derived from the eight subscales of the SF-36). For significance of the test of change = 0 within each cell, NS indicates not significant and all other cells are significant at ≤0.05. Boldface type indicates significance at the P = 0.05 level for the ANOVA test of group differences, after Holm adjustment for three ANOVA tests of the outcome in each of the three adjusted models.